182.
J. Willi, P.A. Küpfer, D. Evéquoz, G. Fernandez G, A. Katz A, C.J. Leumann, N. Polacek
Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center.
Nucleic Acids Research. 2017, 46(4), 1945-1957.
DOI: 10.1093/nar/gkx1308

181.
Y. Hari, C.J. Leumann, S. Schürch
What Hinders Electron Transfer Dissociation (ETD) of DNA Cations?.
Journal of The American Society for Mass Spectrometry. 2017, 28 (12), 2677-2685.
DOI: 10.1007/s13361-017-1791-z

180.
K. Relizani, G. Griffith, L. Echevarria, F. Zarrouki, P. Facchinetti, C. Vaillend, C.J. Leumann, L. Garcia, A. Goyenvalle
Efficacy and Safety Profile of Tricyclo-DNA Antisense Oligonucleotides in Duchenne Muscular Dystrophy Mouse Model.
Molecluar Therapy - Nucleic Acid. 2017, 8, 144-157.
DOI: 10.1016/j.omtn.2017.06.013

179.
A. Istrate, A. Katolik, A. Istrate, C.J. Leumann
2'β-Fluoro-Tricyclo Nucleic Acids (2'F-tc-ANA): Thermal Duplex Stability, Structural Studies, and RNase H activation.
Chemistry - A European Journal. 2017, 23(43), 10310-10318.
DOI: 10.1002/chem.201701476

178.
V. Robin, G. Griffith, J.L. Carter, C.J. Leumann, L. Garcia, A. Goyenvalle
Efficient SMN Rescue following Subcutaneous Tricyclo-DNA Antisense Oligonucleotide Treatment.
Molecular Therapy - Nucleic Acids. 2017, 7, 81-89.
DOI: 10.1016/j.omtn.2017.02.009

177.
S. Diafa, D. Evéquoz, C.J. Leumann, M. Hollenstein
Enzymatic Synthesis of 7',5'-Bicyclo-DNA Oligonucleotides.
Chemistry an Asian Journal. 2017, 12(12), 1347-1352.
DOI: 10.1002/asia.201700374

176.
D. Evéquoz, C.J. Leumann
Probing the backbone topology of DNA: synthesis and properties of 7',5'-bicyclo-DNA.
Chemistry-A European Journal. 2017, 23(33), 7953-7968.
DOI: 10.1002/chem.201700435

175.
P. Roethlisberger, V. Kaliginediand, C. J. Leumann
Modulation of Excess Electron Transfer through LUMO Gradients in DNA Containing Phenanthrenyl Base Surrogates.
Chemistry-A European Journal. 2017, 23(9), 2022-2025.
DOI: 10.1002/chem.201605846

166.
A. Goyenvalle, C. Leumann, L Garcia
Therapeutic Potential of Tricyclo-DNA antisense oligonucleotides.
Journal of Neuromuscular Diseases. 2016, 3(2), 157-167.
DOI: 10.3233/JND-160146

165.
Y. Hari, B. Dugovič, A. Istrate, A. Fignolé, C. J. Leumann, S. Schürch
The Contribution of the Activation Entropy to the Gas-Phase Stability of Modified Nucleic Acid Duplexes.
Journal of The American Society for Mass Spectrometry. 2016, 1-11.
DOI: 10.1007/s13361-016-1391-3

164.
P. Roethlisberger, A. Istrate, M. J. Marcaida Lopez, R. Visini, A. Stocker, J.-L. Reymond and C. J. Leumann
X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair.
Chem. Commun. 2016, 52, 4749-4752.
DOI: 10.1039/C6CC00374E

163.
M. Hollenstein
Generation of long, fully modified, and serum-resistant oligonucleotides by rolling circle amplification.
Org. Biomol. Chem. 2015, 13, 9820-9824.
DOI: 10.1039/C5OB01540E

162.
K. Ahmed, Y. Aoki, T. Koo, G. McClorey, L. Benner, A. Coenen-Stass, L. O'Donovan, T. Lehto, A. Garciaguerra, J.Z. Nordin, A.F. Saleh, M.A. Behlke, J. Morris, A. Goyenvalle, B. Dugovič, C.J. Leumann, S. Gordon, M.J. Gait, S. El-Andaloussi, M.J. Wood
Self-assembly into nanoparticles is essential for receptor mediated uptake of therapeutic antisense oligonucleotides.
Nano letters. 2015, 15, 4364-4374.
DOI: 10.1021/acs.nanolett.5b00490

161.
A. Calabretta, P.A. Küpfer, C.J. Leumann
The effect of RNA base lesions on mRNA translation.
Nucleic acids research. 2015, 43, 4713-4720.
DOI: 10.1093/nar/gkv377

160.
A. Istrate, M. Medvecky, C.J. Leumann
2'-Fluorination of Tricyclo-DNA Controls Furanose Conformation and Increases RNA Affinity.
Organic letters. 2015, 17, 1950-1953.
DOI: 10.1021/acs.orglett.5b00662

159.
M. Medvecky, A. Istrate, C.J. Leumann
Synthesis and Properties of 6'-Fluoro-tricyclo-DNA.
The Journal of organic chemistry. 2015, 80, 3556-3565.
DOI: 10.1021/acs.joc.5b00184

158.
A. Goyenvalle, G. Griffith, A. Babbs, S.E. Andaloussi, K. Ezzat, A. Avril, B. Dugovič, R. Chaussenot, A. Ferry, T. Voit, H. Amthor, C. Bühr, S. Schürch, M.J. Wood, K.E. Davies, C. Vaillend, C.J. Leumann, L. Garcia
Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers.
Nature medicine. 2015, 21, 270-275.
DOI: 10.1038/nm.3765

Research Group of Prof. Christian Leumann © 2017