J. Willi, P.A. Küpfer, D. Evéquoz, G. Fernandez G, A. Katz A, C.J. Leumann, N. Polacek
Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center.
Nucleic Acids Research. 2017, 46(4), 1945-1957.
DOI: 10.1093/nar/gkx1308

Y. Hari, C.J. Leumann, S. Schürch
What Hinders Electron Transfer Dissociation (ETD) of DNA Cations?.
Journal of The American Society for Mass Spectrometry. 2017, 28 (12), 2677-2685.
DOI: 10.1007/s13361-017-1791-z

K. Relizani, G. Griffith, L. Echevarria, F. Zarrouki, P. Facchinetti, C. Vaillend, C.J. Leumann, L. Garcia, A. Goyenvalle
Efficacy and Safety Profile of Tricyclo-DNA Antisense Oligonucleotides in Duchenne Muscular Dystrophy Mouse Model.
Molecluar Therapy - Nucleic Acid. 2017, 8, 144-157.
DOI: 10.1016/j.omtn.2017.06.013

A. Istrate, A. Katolik, A. Istrate, C.J. Leumann
2'β-Fluoro-Tricyclo Nucleic Acids (2'F-tc-ANA): Thermal Duplex Stability, Structural Studies, and RNase H activation.
Chemistry - A European Journal. 2017, 23(43), 10310-10318.
DOI: 10.1002/chem.201701476

V. Robin, G. Griffith, J.L. Carter, C.J. Leumann, L. Garcia, A. Goyenvalle
Efficient SMN Rescue following Subcutaneous Tricyclo-DNA Antisense Oligonucleotide Treatment.
Molecular Therapy - Nucleic Acids. 2017, 7, 81-89.
DOI: 10.1016/j.omtn.2017.02.009

S. Diafa, D. Evéquoz, C.J. Leumann, M. Hollenstein
Enzymatic Synthesis of 7',5'-Bicyclo-DNA Oligonucleotides.
Chemistry an Asian Journal. 2017, 12(12), 1347-1352.
DOI: 10.1002/asia.201700374

D. Evéquoz, C.J. Leumann
Probing the backbone topology of DNA: synthesis and properties of 7',5'-bicyclo-DNA.
Chemistry-A European Journal. 2017, 23(33), 7953-7968.
DOI: 10.1002/chem.201700435

P. Roethlisberger, V. Kaliginediand, C. J. Leumann
Modulation of Excess Electron Transfer through LUMO Gradients in DNA Containing Phenanthrenyl Base Surrogates.
Chemistry-A European Journal. 2017, 23(9), 2022-2025.
DOI: 10.1002/chem.201605846

A. Goyenvalle, C. Leumann, L Garcia
Therapeutic Potential of Tricyclo-DNA antisense oligonucleotides.
Journal of Neuromuscular Diseases. 2016, 3(2), 157-167.
DOI: 10.3233/JND-160146

Y. Hari, B. Dugovič, A. Istrate, A. Fignolé, C. J. Leumann, S. Schürch
The Contribution of the Activation Entropy to the Gas-Phase Stability of Modified Nucleic Acid Duplexes.
Journal of The American Society for Mass Spectrometry. 2016, 1-11.
DOI: 10.1007/s13361-016-1391-3

P. Roethlisberger, A. Istrate, M. J. Marcaida Lopez, R. Visini, A. Stocker, J.-L. Reymond and C. J. Leumann
X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair.
Chem. Commun. 2016, 52, 4749-4752.
DOI: 10.1039/C6CC00374E

M. Hollenstein
Generation of long, fully modified, and serum-resistant oligonucleotides by rolling circle amplification.
Org. Biomol. Chem. 2015, 13, 9820-9824.
DOI: 10.1039/C5OB01540E

K. Ahmed, Y. Aoki, T. Koo, G. McClorey, L. Benner, A. Coenen-Stass, L. O'Donovan, T. Lehto, A. Garciaguerra, J.Z. Nordin, A.F. Saleh, M.A. Behlke, J. Morris, A. Goyenvalle, B. Dugovič, C.J. Leumann, S. Gordon, M.J. Gait, S. El-Andaloussi, M.J. Wood
Self-assembly into nanoparticles is essential for receptor mediated uptake of therapeutic antisense oligonucleotides.
Nano letters. 2015, 15, 4364-4374.
DOI: 10.1021/acs.nanolett.5b00490

A. Calabretta, P.A. Küpfer, C.J. Leumann
The effect of RNA base lesions on mRNA translation.
Nucleic acids research. 2015, 43, 4713-4720.
DOI: 10.1093/nar/gkv377

A. Istrate, M. Medvecky, C.J. Leumann
2'-Fluorination of Tricyclo-DNA Controls Furanose Conformation and Increases RNA Affinity.
Organic letters. 2015, 17, 1950-1953.
DOI: 10.1021/acs.orglett.5b00662

M. Medvecky, A. Istrate, C.J. Leumann
Synthesis and Properties of 6'-Fluoro-tricyclo-DNA.
The Journal of organic chemistry. 2015, 80, 3556-3565.
DOI: 10.1021/acs.joc.5b00184

A. Goyenvalle, G. Griffith, A. Babbs, S.E. Andaloussi, K. Ezzat, A. Avril, B. Dugovič, R. Chaussenot, A. Ferry, T. Voit, H. Amthor, C. Bühr, S. Schürch, M.J. Wood, K.E. Davies, C. Vaillend, C.J. Leumann, L. Garcia
Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers.
Nature medicine. 2015, 21, 270-275.
DOI: 10.1038/nm.3765

Research Group of Prof. Christian Leumann © 2017